Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer. Abstract The toxicity of pharmacologic ascorbate is mediated by the generation of H2O2 via the oxidation of ascorbate. Because pancreatic cancercells are sensitive to H2O2 generated by ascorbate, they would also be expected to become sensitized to agents that increase oxidative damage such as ionizing radiation. The current study demonstrates that pharmacologic… Read More…
vitamin C
Treatment of Pancreatic Cancer with High Dose Intravenous Vitamin C
Treatment of Pancreatic Cancer with Pharmacological Ascorbate Abstract The prognosis for patients diagnosed with pancreatic cancer remains dismal, with less than 3% survival at 5 years. Recent studies have demonstrated that high-dose, intravenous pharmacological ascorbate (ascorbic acid, vitamin C) induces cytotoxicity and oxidative stress selectively in pancreatic cancer cells vs. normal cells, suggesting a promising new role of… Read More…